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KMID : 0617319920020010033
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Journal of Pharmacetical Sceiences Ewha Womans University
1992 Volume.2 No. 1 p.33 ~ p.38
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The Metabolism of Xylazine in Rats
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Park Choo Hea-Young
Choi Sun-Ok
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Abstract
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The biotransformation of xylazine, a widly used animal tranquilizer, was investigated in rats. After administration of xylazine, the existence of 2.6-dimethylphenylsothiocyanate. 2.6-dimenthyl-4-hydroxy-aniline and p-hydroxy-xylazine in urine was confirmed by the comparison with chemically prepared stnadards in GC/MS. The main metabolite. p-hydroxy xylazine was excreted as conjugated form.
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